Trials / Completed
CompletedNCT04696172
Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS)
Explore Potential Plasma Biomarkers of Acute Respiratory Distress Syndrome (ARDS) Using Proteomics Analysis in Patients Undergoing Cardiopulmonary Bypass
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 525 (actual)
- Sponsor
- Huazhong University of Science and Technology · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan. The ARDS events, ventilation time, time of extubation, oxygenation index for 3 days after operation were observed. Plasma samples were collected before CPB, and several time points after CPB. Dynamic differential proteins of ARDS after CPB were screened by DIA (Data independent acquisition) proteomics. Quantitative protein marker concentration was used to predict the occurrence of ARDS after operation, the model discrimination and calibration was assessed.
Conditions
Timeline
- Start date
- 2021-04-01
- Primary completion
- 2022-07-30
- Completion
- 2022-08-30
- First posted
- 2021-01-06
- Last updated
- 2022-12-13
Locations
2 sites across 1 country: China
Source: ClinicalTrials.gov record NCT04696172. Inclusion in this directory is not an endorsement.