NCT04681014

CTEPH in Patients With Prior Pulmonary Embolism and Risk Score Validation

Evidence-based Detection of CTEPH in Patients With Prior Pulmonary Embolism: Risk Score Evaluation and Validation.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,218 (actual)
• Sponsor: iPHNET (italian Pulmonary Hypertension NETwork) · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

CTEPH-SOLUTION aims to create a risk score for the early detection of Chronic Thrombo-Embolic Pulmonary Hypertension (CTEPH) among patients with previous pulmonary embolism. The risk score, created on retrospective data, will be validated on newly diagnosed pulmonary embolism patients.

Detailed description

CTEPH-SOLUTION is a multicenter observational cross-sectional and prospective study in patients with a prior and new diagnosis of pulmonary embolism. Patients with prior pulmonary embolism will be screened at baseline with doppler echocardiography: an estimated sPAP ≥ 40 mmHg will be the indication for pulmonary hypertension detection. After 24 months from baseline, patients will be followed-up for CTEPH detection. CTEPH diagnosis will be carried out according to the current ESC/ERS guidelines. Incident (pulmonary embolism episode at least three months before the baseline) and prevalent (pulmonary embolism episode) patients will be enrolled.

Conditions

• Chronic Thromboembolic Pulmonary Hypertension
• Pulmonary Embolism

Timeline

• Start date: 2016-01-21
• Primary completion: 2020-07-31
• Completion: 2022-07-31
• First posted: 2020-12-23
• Last updated: 2020-12-23

Locations

1 site across 1 country: Italy