Trials / Active Not Recruiting
Active Not RecruitingNCT04657432
Brief, High-dose rTMS for Depression
Accelerated Repetitive TMS for Affective Dysfunction: Establishing the Dose-Response Curve
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- Sponsor
- Medical University of South Carolina · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of individual variations of their functional networks compared to the site of stimulation and clinical outcomes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Repetitive Transcranial Magnetic Stimulation (rTMS) | MagVenture MagPro TMS System would be utilized to deliver 3-minute sessions of intermittent theta burst to left dorsolateral prefrontal cortex. |
Timeline
- Start date
- 2021-05-25
- Primary completion
- 2026-12-01
- Completion
- 2026-12-01
- First posted
- 2020-12-08
- Last updated
- 2026-04-02
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT04657432. Inclusion in this directory is not an endorsement.