NCT04653376

Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases

Possible Relationship Between Apoptosis and Endoplasmic Reticulum Stress in the Etiopathogenesis of Chronic Tonsillitis and Tonsillar Hypertrophy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 46 (actual)
• Sponsor: Selcuk University · Academic / Other
• Sex: All
• Age: 2 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells. The purpose of the study was to explore the correlation among ER stress and tonsillar tissue disorders and to explain the structure of diseases related to the immune system.

Detailed description

A prospective study was conducted on 46 children aged who underwent tonsillectomy for chronic tonsillitis or tonsil hypertrophy. Tonsil tissues were evaluated in terms of ER stress markers and apoptosis markers by Real-time PCR and Western blot methods.

Conditions

• Tonsillitis
• Tonsillar Hypertrophy
• Immune System Diseases

Interventions

Type	Name	Description
PROCEDURE	Tonsillectomy surgery	The tonsillectomy procedure was performed under general anesthesia using the classical dissection method. Extracted tonsil tissue samples were sent to the medical genetics department in tubes to investigate the ER stress and apoptosis.

Timeline

• Start date: 2018-11-01
• Primary completion: 2019-06-10
• Completion: 2019-06-10
• First posted: 2020-12-04
• Last updated: 2020-12-04

Locations

1 site across 1 country: Turkey (Türkiye)