NCT04651166

Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: University of Hawaii · Academic / Other
• Sex: Female
• Age: 14 Years
• Healthy volunteers: Accepted

Summary

Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E). We propose a randomized, double-blinded, placebo-controlled pilot study to determine whether routine use of intravenous (IV) tranexamic acid will decrease the need for interventions to control bleeding at the time of D\&E at 16 to 24 weeks gestation.

Conditions

• Abortion
• Dilation and Evacuation
• Hemorrhage
• Blood Loss

Interventions

Type	Name	Description
DRUG	Tranexamic acid	1g tranexamic acid mixed in 100mL saline or lactated ringer
DRUG	Placebo	100mL saline or lactated ringers

Timeline

• Start date: 2022-02-15
• Primary completion: 2023-07-27
• Completion: 2023-07-27
• First posted: 2020-12-03
• Last updated: 2023-09-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study