NCT04641533

Effect of Dental Pulp Stem Cells and L-PRF After Impacted Third Molar Extraction

Effect of Dental Pulp Stem Cells and L-PRF Placed Into the Extraction Sockets of Impacted Mandibular Third Molars on the Periodontal Status of Adjacent Second Molars: a Split Mouth Randomised Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Baskent University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare the clinical and radiographic effectiveness of Leukocyte-Platelet Rich Fibrin (L-PRF) and L-PRF combined with dental pulp stem cell (DPSC) application to the extraction socket of mandibular third molars.

Detailed description

Patients aged between 18 and 30 years, seeking for bilateral impacted LM3 extraction surgeries and meeting eligibility criteria were included to the study. At baseline right and left impacted third molars (LM3s) were randomly assigned to one of the treatment group (L-PRF and L-PRF + DPSC). Baseline and 6th month clinical and radiographic measurements were compared.

Conditions

• Stem Cell
• Third Molar
• Periodontal Pocket

Interventions

Type	Name	Description
PROCEDURE	L-PRF + DPSC	After surgical removal of impacted mandibular third molars, extraction sockets were filled with L-PRF membranes + DPSCs.
PROCEDURE	L-PRF	After surgical removal of impacted contralateral mandibular third molars, each extraction sockets were only filled with L-PRF membranes.

Timeline

• Start date: 2018-01-20
• Primary completion: 2020-04-10
• Completion: 2020-08-11
• First posted: 2020-11-24
• Last updated: 2020-11-24

Locations

1 site across 1 country: Turkey (Türkiye)