NCT04635488

Prediction Model for Lateral Lymph Node Metastasis

Radiomics-based Prediction Model for Lateral Lymph Node Metastasis in Rectal Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Mid to low-lying rectal cancer patient with enlarged lateral lymph node befor treatment and receiving lateral lymph node dissection would be enrolled. Radiomics parameters of lateral lymph nodes would be extracted by expert software. Then a part of the nodes would be used as the training set to build the prediction model, and the another part nodes would be used as the validation set.

Detailed description

After performing lateral lymph node dissection for the enrolled patients, we would find the targeted lateral node which was matched with the enlarged one in imaging from the specimen. Then the nodes would be send for pathological examination. Then we would extract the radiomics parameters of the nodes from the pretreatment CT and MRI with ITK-SNAP software. According to the pathological status, lymph nodes and corresponding radiomics parameters would be divided into positive and negative groups. Then significant parameters would be selected by R software. Then the prediction model with nomogram would be developed. 70% nodes would be used for for model development and the other 30% would be used for validation.

Conditions

• Rectal Cancer

Interventions

Type	Name	Description
PROCEDURE	lateral lymph node dissection	All participted would receive lateral lymph node dissection for rectal cancer.

Timeline

• Start date: 2020-01-01
• Primary completion: 2021-06-30
• Completion: 2022-12-31
• First posted: 2020-11-19
• Last updated: 2020-11-19

Locations

1 site across 1 country: China