NCT04628754

A Randomized Control Trial of an Intervention to Reverse Frailty and Enhance Resilience Through Exercise and Education

A Randomized Control Trial of a Primary Care Intervention to Reverse Frailty and Enhance Resilience Through Resistance Exercise and Dietary Protein Education (REFEREE) Among Community Dwelling Adults Aged 65 and Over

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 169 (actual)
• Sponsor: University College Dublin · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

Resistance training done at home and protein supplementation may be the most effective and easiest to implement interventions to reverse frailty and build resilience. However, it is not common practice to offer and support such interventions in primary care. This study provides an opportunity to assess the effectiveness of an optimised intervention with community-dwelling adults aged 65 and over, whose baseline clinical frailty score is not worse than mild (i.e. 5 or less), evaluate improvements in health outcomes and demonstrate how the intervention may be incorporated efficiently in clinical practice. The results are intended to encourage mainstream adoption of practical interventions to reverse clinical frailty and build resilience in primary care. An intervention with ten recommended resistance exercises and dietary guidance on protein consumption has been derived from findings of our systematic review and meta-analysis and optimised through a patient and public involvement (PPI) process and feasibility study.

Conditions

• Frailty
• Sarcopenia

Interventions

Type	Name	Description
OTHER	Exercise and protein	Home based exercise regime and dietary protein guidance

Timeline

• Start date: 2020-12-01
• Primary completion: 2021-07-11
• Completion: 2021-07-11
• First posted: 2020-11-13
• Last updated: 2021-12-17

Locations

1 site across 1 country: Ireland