NCT04625569

Genetic of Response to Acute Saline Load Test in Hypertension (Naload)

Role of Genetic Determinants in the Response to Acute Saline Load Testing in Patients With Essential Hypertension (Naload)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Ospedale San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

NHP referred to our outpatient clinic will be enrolled (150 newly recruited) in acute saline test for phenotype characterisation of PNat relationship(7). For each patient we will collect urine and blood samples for standard clinical biochemistry, including electrolytes, creatinine, EO, aldosterone, plasma renin activity, urinary uromodulin (ELISA), urinary and serum uric acid and blood samples for genetic test.

Detailed description

Acute salt load test: after the equilibration period and achievement of a steady state, a constant-rate i.v. infusion of 2 L of 0.9% NaCl was carried out in 2 hours. BP (mean of 3 measurements taken 3 minutes apart) was measured every 30 minutes during the 2 hours of loading and 3 times at 3-min intervals at the end of the infusion. These last 3 BP values were averaged and used in the analysis. The results of these tests will be added to an already collected database of salt load test collected in the previous studies (already published)

Conditions

• Hypertension,Essential
• Salt; Excess
• Genetic Hypertension
• Genetic Predisposition to Disease

Timeline

• Start date: 2019-07-08
• Primary completion: 2023-07-08
• Completion: 2025-09-30
• First posted: 2020-11-12
• Last updated: 2024-05-14

Locations

1 site across 1 country: Italy