NCT04616287

Self and Autobiographical Memory in Dementia With Lewy Bodies and Alzheimer Disease: a Behavioral and Multimodal Neuroimaging Study

Self in Dementia With Lewy Bodies: a Behavioral and Multimodal Neuroimaging Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The present project aims at exploring different components of Self-consciousness or 'the Self', such as autobiographical memory, self-concept and subjective sense of Self, in dementia with Lewy Bodies (DLB) compared to Alzheimer's disease and to normal ageing. Anatomical substrates will be studied in multimodal imaging, in terms of volume, anatomical and functional connectivity. We expect to find an alteration of the different components of the Self, consecutive to insular dysfunction, a key region within cerebral networks of self-consciousness, which is damaged early in the course of the disease.

Conditions

• Dementia With Lewy Bodies
• Alzheimer Disease
• Self
• Autobiographical Memory
• Insular Cortex

Interventions

Type	Name	Description
OTHER	Neuropsychological assessment and Multimodal brain MRI	Neuropsychological assessment and Multimodal brain MRI

Timeline

• Start date: 2021-01-25
• Primary completion: 2023-06-14
• Completion: 2023-10-23
• First posted: 2020-11-04
• Last updated: 2025-10-01

Locations

1 site across 1 country: France