NCT04613193

Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Henrik Wiggers · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis. The study is a randomized (1:1), open label, controlled intervention trial. Hypothesis: 1. Strict BP control for 12 months reduces the progression of LV remodelling compared to conventional treatment. 2. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment. 3. Strict BP reduction for up to 10 years reduces the need for aortic valve replacement and cardiovascular events compared to conventional care.

Conditions

• Aortic Valve Stenosis
• Hypertension,Essential
• Heart Failure

Interventions

Type	Name	Description
OTHER	Blood presssure reduction	Patients will be uptitrated in antihypertensive treatment until the treatment target is achieved.

Timeline

• Start date: 2019-03-01
• Primary completion: 2031-01-01
• Completion: 2031-06-01
• First posted: 2020-11-03
• Last updated: 2020-11-03

Locations

6 sites across 1 country: Denmark