NCT04610645

Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

Live Laser Microscopic Evaluation (OCT) of Radiation Induced Preclinical Alterations of the Skin in Head and Neck Cancer Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Krankenhaus Barmherzige Schwestern Linz · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

Detailed description

Head and neck cancer patients that meet the eligibility criteria and singned the informed consent will undergo OCT-measurements before, during and after the course of radiation therapy. At the same time-points the skin areas are evaluated with dermatoscopy and patients are asked to self-assess their quality of life (EORTC QLQ C30 and respective head and neck module H\&N 43).

Conditions

• Head and Neck Cancer
• Radiotherapy

Interventions

Type	Name	Description
DEVICE	OCT	3x3 OCT volume scans on treated and opposite side of the irreadiated area on head and neck
DEVICE	Dermatoscope	2x2 pictures taken with a dermatoscope

Timeline

• Start date: 2020-06-08
• Primary completion: 2024-12-08
• Completion: 2025-04-08
• First posted: 2020-10-30
• Last updated: 2026-03-03

Locations

1 site across 1 country: Austria