NCT04590456

Pulsed Electromagentic Field in Haemophilia

Efficacy of Pulsed Electromagnetic Field on Hemarthrotic Knee in Haemophilic Adolescence

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Delta University for Science and Technology · Academic / Other
• Sex: Male
• Age: 13 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

To assess the effect of pulsed electero- magnetic field on swelling, range of motion and muscle strength of hemarthrotic knee joints of haemophilic subjects.

Detailed description

Haemophilia is an X-linked hereditary sex recessive disorder that impairs the body's ability to make blood clots. It includes two types: A (FVIII deficit factor) and B (IX deficit factor), depending on FVIII/FIX percentage in blood. The severity of haemophilia is classified into (severe: \<1%, moderate: 1-5%, and mild: \>5%). The prevalence of haemophilia A is 1: 5000 live births and haemophilia B is 1: 30000 live births. This disease is characterized by hemarthrosis which is a hemorrhage in the locomotor system, mainly muscles and joints. Joint bleeding mainly occurs in knees, ankles and elbows. Haemorrhage in the muscle or joints accounts for 80% to 90% of all bleeding episodes in people with haemophilia. The most commonly affected joints in non-prophylaxis patients are the knees (45%) which is thought to be due to the large size of the synovial membrane and large rotational forces present. It is followed by the elbows (30%), ankles (15%), shoulders (3%), and wrists (2%). Bleeds are best detected by the patients themselves as bruising and swelling or described as a feeling of warmth or tingling within the joint preceding the clinical signs. Pulsed electromagnetic field (PEMF) has been reported to be effective in reducing pain, healing of ulcers and promote bone healing, and treating osteoarthritis and inflammatory diseases of the musculoskeletal system. Also, it was reported that PEMF exposure significantly increases the anti-inflammatory effect, suggesting its potential therapeutic use in the treatment of inflammatory bone and joint disorders.

Conditions

• Hemophilia A

Interventions

Type	Name	Description
OTHER	PEMF	group A received 60 minutes of traditional program physical therapy which consisted of passive range of motion, stretching,proprioception, isotonic and isometric and 20 minutes of placebo treatment using PEMF, while group B received the same traditional physical therapy program given to the control group in addition of 20 minutes of PEMF therapy

Timeline

• Start date: 2020-09-01
• Primary completion: 2020-12-19
• Completion: 2020-12-19
• First posted: 2020-10-19
• Last updated: 2020-12-22

Locations

1 site across 1 country: Egypt