NCT04588389

Comparison of Quadratus Lumborum Block Types

Comparison of Quadratus Lumborum Block With Medical Management for Pain Control After Lumbar Spine Fusion Surgery

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Massachusetts, Worcester · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain control after lumbar spinal fusion and if it reduces opioid consumption.

Detailed description

This study is a pilot study as part of planning for a larger randomized controlled trial. The study plans to enroll a total of 30 patients, with 10 patients randomly assigned in each group of the study. Group I will receive the standard of care multimodal pharmacological management. Group II will receive standard of care multimodal pharmacological management plus the Quadratus Lumborum II local anesthetic block. Group III will receive standard of care multimodal pharmacological management plus the Quadratus Lumborum III local anesthetic block. Measurements of opioid use, pain, and side effects will be recorded for each patient.

Conditions

• Pain
• Opioid Use
• Lumbar Disc Herniation

Interventions

Type	Name	Description
DRUG	Ropivacaine injection Location 1	Ropivacaine .5% and lidocaine 1% to the area behind the muscle Quadratus Lumborum location 1
DRUG	Ropivacaine injection Location 2	Ropivacaine .5% and lidocaine 1% to the area behind the muscle Quadratus Lumborum location 2
DRUG	Multimodal Pharmacological Management	standard of care multimodal pharmacological management

Timeline

• Start date: 2020-12-01
• Primary completion: 2021-05-14
• Completion: 2021-05-14
• First posted: 2020-10-19
• Last updated: 2025-07-28
• Results posted: 2025-07-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study