NCT04582110

The Role of OCTA in Patients Affected by Beta Thalassemia

Retinal and Choriocapillaris Vascular Features in Patients With Beta Thalassemia by Means of Optical Coherence Tomography Angiography

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 82 (actual)
• Sponsor: Federico II University · Academic / Other
• Sex: All
• Age: 35 Years – 50 Years
• Healthy volunteers: Accepted

Summary

To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia. Moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (OCT) in these patients

Detailed description

Beta Thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis. The study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.

Conditions

• Thalassemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Optical coherence tomography angiography	Each subject underwent Optical coherence tomography angiography (a non-invasive, fast, diagnostic imaging technique)

Timeline

• Start date: 2019-10-01
• Primary completion: 2020-02-25
• Completion: 2020-02-28
• First posted: 2020-10-09
• Last updated: 2021-02-03

Locations

1 site across 1 country: Italy