NCT04580043

Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors

Experimental Manipulation of OFC Function and Behavioral Context: Towards an Integrative Translational Model of Compulsive Behaviors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 203 (actual)
• Sponsor: Rebecca Price · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a computer task, we will modulate activity in a target brain region and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by targeting the regions of the brain that can help or hinder attempts to overcome compulsions.

Conditions

• Compulsive Behavior
• Obsessive-Compulsive Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Habit Override Practice	Computerized "brain training" to provide practice in overriding avoidance habits.
DEVICE	Transcranial Magnetic Stimulation	Non-invasive method for temporary, focal stimulation of brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
BEHAVIORAL	Sham Training	Computer-based task practice in a non-active/inert task.
DEVICE	Sham Transcranial Magnetic Stimulation	Sham stimulation of non-brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.

Timeline

• Start date: 2020-12-28
• Primary completion: 2025-12-15
• Completion: 2025-12-15
• First posted: 2020-10-08
• Last updated: 2026-02-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study