NCT04579770

Effect of Oral Ketone and Sodium Bicarbonate Administration During Endurance Exercise in Hypoxia

Effect of Oral Ketone and Sodium Bicarbonate Administration on Physiological and Metabolic Parameters During Endurance Exercise in Hypoxia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Jozef Stefan Institute · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study is investigating the effects of oral ketone and sodium bicarbonate administration on physiological and metabolic parameters during cycling endurance exercise in hypoxia. Ketone body supplementation is commonly used among elite endurance athletes that also compete in the hypoxia (at altitude). To-date effects of ketones have only been investigated in normoxia and the data in hypoxia is lacking. Hence, we want to investigate the effect of oral ketone ester intake with and without additional sodium bicarbonate (NaHCO3) ingestion on i) blood-acid base balance and ii) exercise performance during prolonged exercise under hypoxic conditions. Information obtained via this study should provide valuable information with regard to optimisation of exercise training and athletic performance, and more importantly, provide pioneering insight on the metabolic and physiological responses to ketosis under hypoxic conditions.

Conditions

• Exercise
• Hypoxia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone ester	75g ketone ester in the form of a drink \[96% (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, Oxfordshire, UK)\] will be provided.
OTHER	Sodium bicarbonate	Sodium bicarbonate - widely accessible food ingredient will be provided.
OTHER	Placebo	Placebo

Timeline

• Start date: 2020-11-04
• Primary completion: 2020-12-05
• Completion: 2020-12-15
• First posted: 2020-10-08
• Last updated: 2021-02-09

Locations

1 site across 1 country: Belgium