NCT04577443

The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.

To Investigate the Headache Induction and the Cerebral Hemodynamic Changes After Infusion of Adenosine in Healthy Volunteers and Migraine Patient

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Adenosine is a nucleoside that plays a role in both vascular and nociceptive systems, and it has been proposed that adenosine may cause headache in particularly sensitive subjects. Thus, considerable evidence implied that adenosine plays a role in migraine pathophysiology, it is still unknown if intravenous adenosine infusion provokes migraine attacks in healthy subject or in migraine patients. Furthermore, adenosine's effects on the cerebral hemodynamic remains unknown. This study aims to clarify a possible coherence between adenosine and headache/migraine. In general, the study will contribute to a greater understanding of migraine pathogenesis and possibly lead to development of specific migraine treatment.

Conditions

• Headache, Migraine

Interventions

Type	Name	Description
DRUG	Adenosine	To investigate the role of adenosine on cerebral hemodynamic and headache in healthy volunteers and migraine patients
DRUG	Saline	To investigate the role of saline on cerebral hemodynamic and headache in healthy volunteers and migraine patients

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-10-30
• Completion: 2021-10-30
• First posted: 2020-10-08
• Last updated: 2022-11-16

Locations

1 site across 1 country: Denmark