NCT04574765

A Research Platform to Screen Healthcare Workers- Coordinated Approach to Pandemic Trials of COVID-19

A Research Platform to Screen and Protect Individuals That Work Within a Food Production, Healthcare, Research or Clinical Organization - RESPECT

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7,373 (actual)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Recent studies have shown that some individuals may be asymptomatic but continue to shed the COVID-19 virus. These individuals may represent a population that can unknowingly transmit the virus. Healthcare workers (HCW) may acquire COVID-19 from the community or from possibly infected patients. It is important to gather data with respect to this to further understand the prevalence of asymptomatic carriage in individuals who work in research facilities, offices and clinical areas of hospitals and research facilities/institutes since this has important implications for infection control, as well as staff and patient safety. The purpose of this study is to test whether a proportion of these individuals may be asymptomatic shedders of the COVID-19 virus.

Detailed description

Healthcare workers of participating institutions who agree to be participants will: * Fill out some information about participants into a database portal system. Participants will have the ability to check their COVID-19 test results via the portal. * Have nasopharyngeal (NP) swabs done for COVID-19 testing. This can be done about once a week for up to 8 weeks (about 1-8 swabs total). * Provide optional blood samples to look for COVID-19 specific antibodies and/or proteins at the time of enrollment and after 8 weeks. * Fill out questionnaires about participant exposures and travel history, occupation category, any symptoms in the past 21 days, whether they have provided any face-to-face care of a known COVID-19 positive patients in past 14 days or if participants have any children at home who are less than 12 years of age. * Fill out an optional questionnaire about their mental health * Be contacted by telephone if participants are tested positive, to determine whether participants have symptoms of COVID-19, and for the results of any follow-up COVID-19 testing that may have been done.

Conditions

• Healthcare Worker
• Covid19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Nasopharyngeal swab	Nasopharyngeal swab for COVID-19
OTHER	Questionnaire collection (CITF)	Fill out questionnaires regarding exposures and travel history, occupation category, any symptoms in the past 21 days, any face-to-face care of a known COVID-19 positive patients in past 14 days or any children at home who are less than 12 years of age.
OTHER	Optional blood collection	Provide blood samples to look for COVID-19 specific antibodies and/or proteins at the time of enrollment and after 8 weeks.
OTHER	Optional questionnaire completion (mental health)	Fill out an optional mental health questionnaire.
DIAGNOSTIC_TEST	Optional saliva sample (for validation)	Provide saliva sample anonymously.
DIAGNOSTIC_TEST	Nasal Swab (rapid antigen test)	Panbio nasal swab rapid antigen test

Timeline

• Start date: 2020-04-16
• Primary completion: 2021-02-03
• Completion: 2021-02-03
• First posted: 2020-10-05
• Last updated: 2025-07-10

Locations

1 site across 1 country: Canada