NCT04574297

An Observational Study on the Natural Course of Chronic Pancreatitis

The Impact of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis：An Observational Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 798 (actual)
• Sponsor: Changhai Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.

Detailed description

The present study was an observational study aimed to explore the impact of genetic factors (rare pathogenic variants of CP) and environmental factors(smoking and alcohol assumption) on the clinical manifestation and progression of CP. The observation items included the pain patterns, incidence of complications of CP, pancreatic cancer and death.

Conditions

• Chronic Pancreatitis
• Genetic Mutation
• Smoking, Tobacco
• Drinking, Alcohol

Interventions

Type	Name	Description
BEHAVIORAL	smoking and alcohol assumption	documenting the change of smoking and drinking status during the follow-up period
DIAGNOSTIC_TEST	genetic sequencing	sequencing the susceptibility genes for CP, including serine protease inhibitor Kazal type 1, cationic trypsinogen, cystic fibrosis transmembrane conductance regulator, chymotrypsin C, etc.

Timeline

• Start date: 2011-01-01
• Primary completion: 2020-05-31
• Completion: 2030-12-31
• First posted: 2020-10-05
• Last updated: 2021-11-30
• Results posted: 2021-11-30