NCT04569708

Sleep Spindles and Memory in Rolandic Epilepsy

Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 4 Years – 18 Years
• Healthy volunteers: Accepted

Summary

The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Detailed description

This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.

Conditions

• Rolandic Epilepsy
• Rolandic Epilepsy, Benign
• Centrotemporal Epilepsy
• Centrotemporal; EEG Spikes, Epilepsy of Childhood
• Epilepsy; Seizure
• Epilepsy

Interventions

Type	Name	Description
OTHER	Auditory stimulation	Quiet auditory stimulation timed with sleep physiology

Timeline

• Start date: 2021-01-16
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2020-09-30
• Last updated: 2024-11-20

Locations

1 site across 1 country: United States