NCT04567147

Effect of Probiotic on Depression

Effect of Probiotic on Depressive Symptom in Chinese Patients

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 89 (actual)
• Sponsor: China Agricultural University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Depressive disorder, also known as depression, is a type of mood disorder characterized by persistent low mood. The incidence of depression worldwide is about 6%. Growing evidence suggested that the gut microbiota plays a key role in the development of depression. Probiotics can effectively regulate gut microbiota, and showed potential in alleviating depression. This study investigated the effect of formula probiotic (containing Lactobacillus paracasei, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium bifidum and Lactobacillus plantarum) on depression.

Conditions

• Depression

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	Patients received the formula probiotic for consecutive 8 weeks ( one sachet per day ).
DIETARY_SUPPLEMENT	Placebo	Patients received the placebo identical to probiotic for consecutive 8 weeks ( one sachet per day ).

Timeline

• Start date: 2018-11-20
• Primary completion: 2019-06-22
• Completion: 2020-09-12
• First posted: 2020-09-28
• Last updated: 2020-09-28

Locations

1 site across 1 country: China