NCT04553835

Effects of Rhythmic Auditory Stimulation on Movements in Individuals at Risk for Psychotic Onset and Schizophrenia Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Dr WANG Shumei · Academic / Other
• Sex: All
• Age: 13 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to examine effects of movement training with the aid of rhythmic auditory stimulation (RAS) on reducing severity of dyskinesia and bradykinesia in at-risk individuals and schizophrenia patients. The investigators hypothesize that training with the aid of RAS reduced severity of bradykinesia and dyskinesia in at-risk individuals as well as in schizophrenia patients.

Conditions

• Schizophrenia
• Psychosis
• Parkinsonism
• Dyskinesias

Interventions

Type	Name	Description
BEHAVIORAL	Rhythmic auditory stimulation (RAS) for schizophrenia patients	A mobile application, "metronome beats" developed by Stonekick Limited, will be used to give RAS when the participant executes the movement. Before intervention, the participant is required to execute the movement task without the aid of RAS as quickly as possible for 30 seconds, so that we obtain his/her baseline movement tempo (beats per minute). For each 40-minute training session in the first training week, three RAS tempi will be provided for the first, second, and last 10 minutes with a five-minute break in between: normal (100% of the baseline tempo), quick (105% of the baseline tempo), and fast (110% of the baseline tempo). With each training week, the three RAS tempi will be increased by 5%. Schizophrenia patients in the experimental group will undergo upper limb movement training with the aid of RAS. The intervention protocol will last for 3 weeks on the weekday basis (a total of 15 sessions) with one session (40 minutes) per weekday.
BEHAVIORAL	No RAS for schizophrenia patients	The training protocol will be the same as that used in the experimental group except the lack of RAS during execution of the movement task.
BEHAVIORAL	RAS for at-risk individuals	A mobile application, "metronome beats" developed by Stonekick Limited, will be used to give RAS when the participant executes the movement. Before intervention, the participant is required to execute the movement task without the aid of RAS as quickly as possible for 30 seconds, so that we obtain his/her baseline movement tempo (beats per minute). For each 40-minute training session in the first training week, three RAS tempi will be provided for the first, second, and last 10 minutes with a five-minute break in between: normal (100% of the baseline tempo), quick (105% of the baseline tempo), and fast (110% of the baseline tempo). With each training week, the three RAS tempi will be increased by 5%. At-risk individuals in the experimental group will undergo upper limb movement training with the aid of RAS. The intervention protocol will last for 3 weeks on daily basis (a total of 21 sessions), with one training session (40 minutes) per day.
BEHAVIORAL	No RAS for at-risk individuals	The training protocol will be the same as that used in the experimental group except the lack of RAS during execution of the movement task.

Timeline

• Start date: 2020-08-31
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2020-09-17
• Last updated: 2022-05-23

Locations

1 site across 1 country: Hong Kong