NCT04549974

Characterization of Myocardial Blood Flow During Heat Exposure

Characterization of the Increase and Distribution of Myocardial Blood Flow During Heat Exposure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Montreal Heart Institute · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.

Detailed description

As a result of climate change, heat waves are more frequent and of longer duration. These heat waves are associated with a higher risk of hospitalization and mortality in vulnerable populations such as people with cardiovascular disease or cardiovascular risk factors. It has been hypothesized that this observation may be explained by the cardiovascular demands imposed by heat exposure. Heat exposure requires increased cardiac work that may place individuals with cardiovascular disease at risk of ischemic events if the metabolic demand is not compensated by adequate blood supply. However, the extent to which cardiac work increases during heat exposure remains unknown. The aim of this study is to test the hypothesis that heat exposure increases myocardial blood flow and that this increase is affected by age and coronary artery disease.

Conditions

• Hot Weather; Adverse Effect
• Healthy
• Coronary Artery Disease
• Aging

Interventions

Type	Name	Description
OTHER	Heat exposure	Participants will be exposed to heat exposure via a water-perfused suit to increase internal body temperature by 1.5 degrees Celsius.

Timeline

• Start date: 2020-08-25
• Primary completion: 2023-03-31
• Completion: 2023-03-31
• First posted: 2020-09-16
• Last updated: 2023-05-08

Locations

1 site across 1 country: Canada