NCT04542655

The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01)

An Open-label, Single-center, Randomized, Controlled, Exploratory Study to Investigate the Effect of Weight Bearing Versus Non-weight Bearing Exercise on Collagen and Proteoglycan in Serum and Urine in Patients With Osteoarthritis and Healthy Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Nordic Bioscience A/S · Industry
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Aim of EFEX-OA-01: To explore how running, cycling and resting acutely influence levels of collagen and proteoglycan in patients with osteoarthritis knee and in young healthy subjects, as reflected by changes in serum and urine biochemical markers originating from joint related collagens and proteoglycans.

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
OTHER	Ergometer Cycling followed by treadmill running	The participants undergo ergometer cycling, treadmill running and rest.
OTHER	Treadmill Running followed by ergometer cycling	The participants undergo treadmill running, ergometer cycling and rest.
OTHER	Rest	The participants undergo ergometer cycling, treadmill running and rest.

Timeline

• Start date: 2019-01-07
• Primary completion: 2019-05-14
• Completion: 2019-05-14
• First posted: 2020-09-09
• Last updated: 2021-02-15

Locations

1 site across 1 country: Denmark