NCT04540055

General Anesthesia and Paravertebral Blocks vs. General Anesthesia Only: Influence Inflammation Factors and Clinical Outcomes in Modified Radical Mastectomy

Effects of General Anesthesia vs. General Anesthesia and Paravertebral Block to IL-2, IL-6, PGE2, MMP-9, and Clinical Outcome in Modified Radical Mastectomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 88 (actual)
• Sponsor: Udayana University · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Regional anesthesia and analgesia may maintain immune function, reduce surgical stress, and also reduce volatile anesthetics and opioids requirements. Local anesthetic drugs used in regional anesthesia and analgesia work to have anti-proliferative and cytotoxic effects on cancer cells. Pro-inflammatory cytokines such as IL-1, IL-6, and TNF-alpha increase in levels in peripheral nerves, spinal cord, brain (brain stem, locus sereleus, thalamus, hippocampus, and prefrontal cortex) after peripheral nerves are injured. The anti-inflammatory cytokine IL-10 is decreased in levels after peripheral nerve injury. The balance between pro-inflammatory and anti-inflammatory cytokines affects the severity of pain.

Conditions

• Anesthesia, Local
• Anesthesia
• Inflammatory Response
• Pain, Postoperative

Interventions

Type	Name	Description
PROCEDURE	Paravertebral block	The subjects in this group received general anesthesia and USG-guided paravertebral block
PROCEDURE	General Anesthesia	The subjects in this group underwent MRM under routine general anesthesia without peripheral nerve block supplementation.

Timeline

• Start date: 2020-10-01
• Primary completion: 2020-12-30
• Completion: 2021-01-21
• First posted: 2020-09-07
• Last updated: 2021-01-22

Locations

1 site across 1 country: Indonesia