NCT04539223

A Study of Evolocumab on Carotid Artery Atherosclerotic Plaque Morphology Prior to Carotid EndArterectomy

Study of Lipids Inside the Carotid With Evolocumab: A Randomized Trial of Evolocumab on Carotid Artery Atherosclerotic Plaque Morphology Prior to Carotid EndArterectomy (SLICE-CEA CardioLink-8 Study)

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Canadian Medical and Surgical Knowledge Translation Research Group · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

This is a multicenter, randomized, open label study with blinded outcome assessment to evaluate the impact of additional/intensive LDL-cholesterol reduction with evolocumab on carotid artery atherosclerotic plaques in higher risk subjects with severe asymptomatic but vulnerable plaques.

Conditions

• Carotid Artery Stenosis
• Asymptomatic Carotid Artery Stenosis

Interventions

Type	Name	Description
DRUG	Evolocumab	Autoinjector 1-mL deliverable volume of 140 mg/mL

Timeline

• Start date: 2020-08-28
• Primary completion: 2022-04-01
• Completion: 2022-05-01
• First posted: 2020-09-04
• Last updated: 2022-05-02

Locations

3 sites across 1 country: Canada