Trials / Completed
CompletedNCT04538144
Cardiovascular Responses to Heat Waves in the Elderly
Heat Waves in the Elderly: Reducing Thermal and Cardiovascular Consequences
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 59 (actual)
- Sponsor
- University of Texas Southwestern Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
Detailed description
Heat waves are lethal and cause a disproportionate number of deaths in the elderly relative to any other age group. It is important to note that such deaths are primarily cardiovascular, not hyperthermia itself, in origin. Nevertheless, we know relatively little about the effects of aging on cardiovascular function during actual heat wave-like conditions. The central hypothesis of this work is that the elderly exhibit greater cardiovascular stress during heat wave conditions. Aim 1 will test the hypothesis that recognized impairments in thermoregulatory capacity in the elderly will culminate in heightened cardiovascular stress during prolonged exposure to heat wave conditions. Comprehensive cardiovascular and thermal responses in the elderly, relative to younger adults, will be evaluated during exposure to two prolonged heat wave conditions: hot and humid (replicating the 1995 Chicago heat wave) and very hot and dry (replicating the 2018 Los Angeles heat wave). The expected outcome from this body of work will re-shape our understanding of the consequences of aging on cardiovascular function during heat waves
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Hot and Humid Trial | Individuals will be exposed to a simulated heat wave (hot and humid) condition. |
| OTHER | Hot and Dry Trial | Individuals will be exposed to a simulated heat wave (hot and dry) condition. |
Timeline
- Start date
- 2021-01-19
- Primary completion
- 2023-02-20
- Completion
- 2023-02-20
- First posted
- 2020-09-03
- Last updated
- 2025-10-23
- Results posted
- 2025-08-07
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04538144. Inclusion in this directory is not an endorsement.