NCT04536194

Dopamine Versus Norepinephrine Under General Anesthesia

Hemodynamic Effects of Dopamine Versus Norepinephrine Under General Anesthesia in Infant With Congenital Heart Disease

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Children's Hospital of Fudan University · Academic / Other
• Sex: All
• Age: 1 Month – 12 Months
• Healthy volunteers: Not accepted

Summary

Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.

Detailed description

After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.

Conditions

• Anesthesia
• Infant
• Congenital Heart Disease
• Hemodynamic Instability

Interventions

Type	Name	Description
DRUG	norepinephrine	to treat hypotension under general anesthesia with norepinephrine
DRUG	dopamine	to treat hypotension under general anesthesia with dopamine

Timeline

• Start date: 2020-10-10
• Primary completion: 2021-08-31
• Completion: 2021-09-30
• First posted: 2020-09-02
• Last updated: 2021-10-22

Locations

1 site across 1 country: China