NCT04530760

Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation

Impact of Intraabdominal Hypertension on Microaspiration Incidence in Cirrhotic Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 226 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.

Detailed description

Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation. Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.

Conditions

• Critical Illness
• Cirrhosis, Liver

Timeline

• Start date: 2021-10-08
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2020-08-28
• Last updated: 2025-12-23

Locations

2 sites across 1 country: France