NCT04525768

Gastroesophageal Varices in Cavernoma

Characteristic of Patients With Gastroesophageal Varices and Portal Cavernoma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: —

Summary

Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, may lead to gastroesophageal varices. The quality of life, morbidity, and mortality of MPN patients mainly depend on disease-related symptoms, thromboembolic and hemorrhagic complications. Previous studies have shown that JAK2 V617F has a prominent role in vascular risk and MPN-associated gastroesophageal varices. Portal vein thrombosis and portal cavernoma frequently occur in the MPN population and the management of gastroesophageal varices in these patients are sometimes technically difficult. The aim of this study is to investigate the the characteristics of patients with gastroesophageal varices and portal caver cavernoma with or without JAK2 mutation.

Conditions

• Gastroesophageal Varices
• Myeloproliferative Neoplasm
• Portal Caver Cavernoma
• Portal Hypertension

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	JAK2 mutation test	Patients with portal caver cavernoma will be divided into two groups by the result of JAK2 mutation test

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-09-30
• Completion: 2022-09-30
• First posted: 2020-08-25
• Last updated: 2020-08-25

Locations

1 site across 1 country: China