NCT04515342

Sarcopenia, Fall and Osteoporosis in Chronic Kidney Disease

Sarcopenia, Fall and Osteoporosis in Patients With Chronic Kidney Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 140 (estimated)
• Sponsor: Herlev Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 120 Years
• Healthy volunteers: —

Summary

This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.

Detailed description

Sarcopenia is a condition diagnosed from different clinical findings such as low muscle mass, low muscle strength and possibly also poor physical performance. In the general population, the risk of fall and bone fracture increases, when sarcopenia is also present. Sarcopenia is known to occur in patients with chronic kidney disease, but whether, and if so, how this differs from the incidence in patients without kidney disease has not previously been described. Patients with chronic kidney disease have a 3 times higher risk of bone fracture compared to the Danish background population, and they also have an increased risk of falls. The association between sarcopenia, risk of falls and osteoporosis in patients with kidney disease is until now sparsely described, and because of this, the investigators want to explore this further in this cross-sectional study.

Conditions

• Sarcopenia
• Chronic Kidney Diseases
• Osteoporosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	DXA	Each participant will undergo one DXA scan
OTHER	Muscle strength and function assessment	Each patient will have their muscle strength and function assessed with the measurements of handgrip strength, 10 m gait speed and a 30 s sit-to-stand test. They will also fill out a questionnaire assessing Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls (SARC-F questionnaire).
OTHER	Blood samples	Each patient will undergo a physical examination and also deliver blood samples.

Timeline

• Start date: 2021-03-10
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2020-08-17
• Last updated: 2024-04-22

Locations

2 sites across 1 country: Denmark