NCT04513808

Total Intravenous Anesthesia and Recurrence Free Survival

Total IntraVenous AnesthesIa and ReCurrence-free Survival AfTer EsOphageal CanceR SurgerY

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,614 (estimated)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.

Detailed description

The investigators will test the primary hypothesis that recurrence-free survival after esophageal cancer surgery is longer in patients randomized to propofol-based total intravenous anesthesia than to volatile sevoflurane anesthesia. The investigators will test the secondary hypotheses that propofol-based total intravenous anesthesia: 1) speeds discharge from the ICU; 2) speeds discharge from the hospital; and, 3) improves the quality of recovery, as assessed by QoR-15 on postoperative day 2.

Conditions

• Esophageal Cancer

Interventions

Type	Name	Description
DRUG	Propofol-based total intravenous anesthesia	Propofol-based total intravenous anesthesia, titrated to clinical need.
DRUG	Sevoflurane intravenous anesthesia	Sevoflurane intravenous anesthesia, titrated to clinical need.

Timeline

• Start date: 2020-08-15
• Primary completion: 2025-12-01
• Completion: 2027-12-01
• First posted: 2020-08-14
• Last updated: 2024-12-04

Locations

1 site across 1 country: China