NCT04506021

A Real World Study on Clinical Efficacy of Bicarbonate Ringer's Solution in Biliary Atresia Children

A Multicenter Real World Study on Clinical Efficacy of Sodium Bicarbonate Ringer's Solution in Children With Biliary Atresia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 110 (estimated)
• Sponsor: Tongji Hospital · Academic / Other
• Sex: All
• Age: 90 Days
• Healthy volunteers: Not accepted

Summary

In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver. The surgery called the Kasai procedure and eventually, a liver transplant could treat biliary atresia. However, children with BA have poor liver function, poor renal reserve, and poor ability to regulate water and electrolytes. Therefore, A reasonable and effective perioperative fluid management is more significant. Considering the high chlorine of saline, the liver burden of Lactated Ringer's solution and Acetated Ringer's solution, the Bicarbonate Ringer's solution which composition is similar to plasma, could be the best choice for perioperative fluid management of BA children. Therefore, we hypothesize that compared with other crystalloids, Bicarbonate Ringer's solution is a better choice to maintain water, electrolyte and acid-base balance in BA children.

Conditions

• Biliary Atresia

Interventions

Type	Name	Description
DRUG	Bicarbonate Ringer's solution	According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. no Intervention.
DRUG	Other Crystalloid	According to the choices of the patients' immediate family members, patients will be divided into other clinical used crystalloid. no Intervention.

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-08-01
• Completion: 2021-10-01
• First posted: 2020-08-10
• Last updated: 2020-08-10