NCT04499664

Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 25 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: Male
• Age: 30 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV). Decreased HRV has been shown to be predictive of morbidity and mortality in diverse medical conditions such as acute myocardial infarction, aneurysmal subarachnoid haemorrhage, autoimmune diseases, sepsis and surgery. The function of the autonomic nervous system has not yet been investigated in a "pure hypovolemia" model. The aim of the current study is therefore to investigate and describe the function of the autonomic nervous system prior to, during and after reduction of blood volume in healthy blood donors.

Conditions

• Autonomic Dysfunction
• Autonomic Imbalance
• Blood Loss

Interventions

Type	Name	Description
DEVICE	Monitoring of the autonomic nervous system	Monitoring of the autonomic nervous system using E-patch, LiDCO and Root-Massimo.

Timeline

• Start date: 2020-08-01
• Primary completion: 2020-09-01
• Completion: 2022-06-01
• First posted: 2020-08-05
• Last updated: 2022-08-30

Locations

1 site across 1 country: Denmark