NCT04495491

Predicting the Effect of Laser Peripheral Iridotomy

Prediction of the Degree of Angle Opening Distance in Patients With Primary Angle Closure Suspect After Laser Peripheral Iridotomy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the angle parameters of patients with PACS before and after LPI. The investigators will analyze the results of patients with different angle closure mechanisms before and after LPI, and participants hope to find the structural parameters for predicting the effect of LPI.

Detailed description

Primary angle-closure glaucoma is the leading cause of blindness worldwide. It is associated with increased intraocular pressure, which causes optic nerve damage and field defects if untreated. The aqueous humor leaves the anterior chamber through the trabecular meshwork and flows into the aqueous vein and the superior scleral vein through the collector channels and Schlemm's canal. If the trabecular meshwork is not blocked, a wide angle allows enough aqueous humor to drain out. The iris corneal translocation may lead to angle-closure glaucoma. Laser peripheral iridectomy is recognized as the best surgical method to relieve pupil block. Previous studies have shown increased anterior chamber depth (ACD), area (ACA), and volume (ACV), and increased Angle open distance (AOD) after LPI surgery. However, postoperative outcomes of LPI were not the same for patients with different angle closure mechanisms. Postoperative outcomes for LPI were best for patients with pupillary block type, but were moderate for patients with plateau iris group and mixed group. The purpose of this study, conducted in Chinese subjects, aims to use UBM to evaluate changes in the anterior segment parameters of LPI, and to propose methods to predict postoperative outcomes of LPI.

Conditions

• Glaucoma

Interventions

Type	Name	Description
OTHER	pupillary block group	According to the configurations of angle closure, the pupillary block group is defined as the iris bombe.
OTHER	plateau iris group	According to the configurations of angle closure, the plateau iris group is defined as the thickness of the peripheral iris.
OTHER	mixing mechanism group	According to the configurations of angle closure, the mixing mechanism group is defined as the iris bombe plus thickening of the peripheral iris.

Timeline

• Start date: 2020-07-01
• Primary completion: 2020-12-31
• Completion: 2021-03-31
• First posted: 2020-07-31
• Last updated: 2020-07-31

Locations

1 site across 1 country: China