Trials / Completed
CompletedNCT04487730
Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 64 (actual)
- Sponsor
- Weill Medical College of Cornell University · Academic / Other
- Sex
- All
- Age
- 50 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-life depression. Use of computational modeling will enable identification of neuroimaging and behavioral profiles associated with greater treatment response, and may guide future personalization of psychotherapy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | "Engage & Connect" Psychotherapy | 9-weeks of weekly psychotherapy sessions focused on social reward exposure |
| BEHAVIORAL | Symptom Review and Psychoeducation (SRP) | 9-weeks of weekly psychotherapy sessions focused on symptom review and psychoeducation about depression and aging |
Timeline
- Start date
- 2020-10-15
- Primary completion
- 2024-08-13
- Completion
- 2024-08-19
- First posted
- 2020-07-27
- Last updated
- 2025-06-03
- Results posted
- 2025-06-03
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04487730. Inclusion in this directory is not an endorsement.