NCT04482660

Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Barcelonabeta Brain Research Center, Pasqual Maragall Foundation · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Accepted

Summary

This study will characterize tau tracer retention by Positron Emission Tomography (PET) as a function of amyloid levels transversally and longitudinally.

Detailed description

CROSS-SECTIONAL OBJECTIVES * To measure 18F-RO6958948 retention in selected participants of ALFA-related studies as a function of amyloid levels. * To study the relation between 18F-RO6958948 retention and amyloid levels. * To characterize imaging correlates as a function of tau and amyloid levels. * To study the role of tau retention on cognitive performance. * To define predictors of tau retention. LONGITUDINAL OBJECTIVES * To measure tau accumulation and spreading in participants of the ALFA-related studies of BBRC as a function of baseline amyloid levels. * To study the dynamic relation between tau spreading and amyloid levels longitudinally. * To define predictors of tau spreading.

Conditions

• Healthy
• Mild Cognitive Impairment

Interventions

Type	Name	Description
PROCEDURE	Positron emission tomography with 18F-RO6958948	tau PET ()

Timeline

• Start date: 2021-03-29
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2020-07-22
• Last updated: 2025-05-31

Locations

1 site across 1 country: Spain