NCT04482374

Puberty Suppression and Cardiometabolic Health

Effects of Puberty and Pubertal Suppression on Insulin Sensitivity, Metabolic Rate and Vascular Health

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: Male
• Age: 9 Years – 14 Years
• Healthy volunteers: —

Summary

This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin releasing hormone agonist compared to matched cisgender male controls.

Conditions

• Transgenderism
• Insulin Sensitivity/Resistance
• Endothelial Dysfunction
• Vascular Stiffness

Timeline

• Start date: 2020-08-10
• Primary completion: 2026-07-31
• Completion: 2026-07-31
• First posted: 2020-07-22
• Last updated: 2025-06-10

Locations

1 site across 1 country: United States