NCT04481295

Study on Optimal Oxygen Concentration During Pulmonary Rehabilitation

Effect of Pulmonary Rehabilitation Under Different Oxygen Concentration Using High-flow Nasal Cannula

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: National Hospital Organization Minami Kyoto Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the exercise capacity between high SpO2 (Minimum SpO2 94-96%) value during pulmonary rehabilitation and low SpO2 (Minimum SpO2 84-86%) value during pulmonary rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.

Detailed description

In patients with chronic respiratory failure, pulmonary rehabilitation is recognized as an evidence-based treatment in improving exercise capacity, muscle strength, dyspnea, and quality of life. However, optimal SpO2 value during pulmonary rehabilitation in patients with chronic respiratory failure receiving long-term oxygen therapy is unclear. The present study is randomized to compare the effect of exercise capacity between high SpO2 (Minimum SpO2 94-96%) value during pulmonary rehabilitation and low SpO2 (Minimum SpO2 84-86%) value during pulmonary rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.

Conditions

• High-flow Nasal Cannula
• Exercise Capacity
• Chronic Respiratory Failure
• Optimal SpO2 Value

Interventions

Type	Name	Description
OTHER	High-flow nasal cannula	The nasal high flow therapy has enabled high flow oxygen to be derived through nasal cannula. This mode not only allows constant FiO2 during peak inspiratory flow but also confers benefits including a low level of continuous positive airway pressure with increased end-expiratory lung volume and reduced work of breathing, partly through intrinsic positive end-expiration pressure compensation and dead space washout. The inspired gases are warmed and humidified, improving comfort and possibly reducing airway inflammation, leading to improved drainage of respiratory secretions.
OTHER	Low SpO2	Low SpO2

Timeline

• Start date: 2020-07-18
• Primary completion: 2025-07-01
• Completion: 2025-07-01
• First posted: 2020-07-22
• Last updated: 2023-03-28

Locations

1 site across 1 country: Japan