NCT04476615

Effects of Fasting-Mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance

Effects of Fasting-mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Universita di Verona · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to test a Fasting Mimicking Diet (FMD) for its efficacy on improving muscular resistance and endurance. The investigators will perform a randomized clinical trial to test the efficacy of the FMD on improving muscular strength, muscular resistance and endurance in physically active young adults (18-40 years of age). The study will include two arms: Placebo (Placebo diet) and FMD (3 cycles of 5-day fasting-mimicking diet within two months). Study endpoints will include muscular strength evaluation of lower limbs, cardio-pulmonary responses, neuromuscular function and muscle architecture. Subjects will be evaluated 4 times within 3 months: at baseline (T1), after the 1st cycle of diet (T2), 7 to 15 days after the 3rd cycle of diet maintaining baseline intensity (T3) and with re-assessment of Peak Power Output (T4).

Conditions

• Fatigue; Muscle, Heart
• Fasting
• Diet, Healthy
• Fatigue, Mental

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fasting-Mimicking Diet (ProLon®)	Dietary restriction: Fasting-Mimicking Diet (ProLon®). 5-days cycles spaced at 1-month intervals for 3 months (3 cycles in total).
DIETARY_SUPPLEMENT	Placebo bars	Dietary supplementation: Low-energy bars (L-Nutra®) to integrate the daily nutritional habits - one bar per day. 5-days cycles spaced at 1-month intervals for 3 months (3 cycles in total).

Timeline

• Start date: 2017-12-04
• Primary completion: 2020-01-16
• Completion: 2020-01-16
• First posted: 2020-07-20
• Last updated: 2020-07-20

Locations

1 site across 1 country: Italy