NCT04474431

Correlation of VEGF-A and Fluid Balance in Septic Shock

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 103 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

VEGF is a key molecule in the control of vascular permeability via interactions with the VEGF-receptor on the endothelial cell. Several authors reported plasma VEGF levels are elevated in sepsis shock and associated with increased mortality (1,2). In septic shock, the main elements of treatment are intravenous fluids, appropriate antibiotics and vasopressors. Some authors observed positive fluid balance is associated with increased mortality rates in patients (3,4). To the best of our knowledge, no studies have shown a correlation between VEGF levels and the fluid balance. The aim of our study was to determine the role of VEGF in capillary leakage and the positive fluid balance in septic shock.

Conditions

• Septic Shock

Interventions

Type	Name	Description
OTHER	Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.	Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.

Timeline

• Start date: 2019-12-24
• Primary completion: 2023-10-17
• Completion: 2023-10-17
• First posted: 2020-07-16
• Last updated: 2026-02-06

Locations

1 site across 1 country: France