NCT04465565

Fluids Administration During Combined Clonidine-Arginine Growth Hormone Stimulation Test

Fluids Administration During Combined Clonidine-Arginine Growth Hormone Stimulation Test- Randomized, 2 Arms, Controlled Study

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Rabin Medical Center · Academic / Other
• Sex: All
• Age: 7 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

The diagnosis of Growth Hormone deficiency in childhood requires the performance of an artificial pharmacological stimulation tests. There are number of substances that increase the secretion of growth hormone, among them Clonidine and Arginine. One of the possible side effects of both Clonidine and Arginine is a reduction in the blood pressure due to a decreased heart output and declined contraction of peripheral blood vessels. In cases where values of blood pressure at the end of the test are not recovered after two sessions of 15 minutes of physical activity, the patient is treated with I. V of 9%NORMAL SALINE (0. 20cc /Kg) administrated over 30-60 minutes. The aim of the proposed study is to test whether administration of fluids during the combined Growth Hormone stimulation test Clonidine-Arginine will help in the recovery process from the test (blood pressure \> 90/50 mmHg after performing physical activity defined as 15-minutes hike in two consecutive sessions). The study design will be randomized, controlled, 2 arms study.

Conditions

• Growth Hormone Deficiency

Interventions

Type	Name	Description
PROCEDURE	9% Sodium Chloride (NaCl) IV	9% Sodiun Chloride (NaCl) ( 20cc/kg) adminstrated intravenously

Timeline

• Start date: 2020-12-01
• Primary completion: 2022-08-01
• Completion: 2022-08-01
• First posted: 2020-07-10
• Last updated: 2022-02-22

Locations

1 site across 1 country: Israel