NCT04459741

HIV, Immune Activation and Salt Sensitive Hypertension

Hypertension, Dietary Salt and Inflammation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: Mulungushi University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

High dietary salt is associated with immune activation, elevated levels of inflammatory cytokines and hypertension in murine models. Hypertension is independently associated with inflammation in both murine studies and studies in humans. In people living with HIV, these interactions are not well established. The aim of this study is to determine the effect of excess dietary salt on immune cell activation, pro- and anti-inflammatory cytokines and blood pressure between individuals with and without hypertension among people living with HIV and HIV negative persons.

Conditions

• HIV-1-infection
• Hypertension,Essential

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Dietary salt (Sodium chloride)	Dietary salt used was sodium chloride tablets (from the research consolidated midland corporation division, New York, USA) which participants crashed and put in their food and/or ingested. Each tablet weighed one (1) gram and contained 394 mg of sodium and 606 mg of chloride.

Timeline

• Start date: 2019-01-02
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2020-07-07
• Last updated: 2020-07-07

Locations

1 site across 1 country: Zambia