NCT04455204

Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in Preeclampsia

Implication of Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in the Pathogenesis of Preeclampsia and in Pregnancy Related Complications

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 25 Years – 35 Years
• Healthy volunteers: —

Summary

The aim of the present study is to evaluate the implication of adipokines, inflammation, insulin resistance and endothelial dysfunction in the pathogenesis of preeclampsia and in pregnancy related complications.

Detailed description

This observational parallel study will be conducted on pregnant women with normal pregnancy, pregnant women with Preeclampsia, and on healthy non-pregnant women. All participants will be recruited from the Outpatient Clinic of Obstetrics and Gynecology Department at Menoufia University Hospital (Shebin El-Kom, Egypt). The study will be approved by the Research Ethics Committee of Menoufia University and all the involved subjects will give their written informed consent. This study will involve a total number of 60 women who will be further classified into: 20 non-pregnant women who serve as the control group (group 1), 20 pregnant women with normal pregnancy at their third trimesters (group 2) and 20 pregnant women with Preeclampsia at their third trimester (group 3) will be screened to fit the inclusion and exclusion criteria. The pregnant women will be assessed in their third trimesters and further re-evaluated 4 weeks after delivery. The gestational ages will be determined conventionally and re-affirmed by ultrasonographic measurement.

Conditions

• Pre-Eclampsia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum asymmetteric dimethyl arginine	Serum asymmetteric dimethyl arginine (ADMA) will be done using Enzyme-Linked Immunosorbent Assay
DIAGNOSTIC_TEST	serum lipid profiles	serum lipid profiles including triglycerides (TG), total cholesterol and high-density lipoprotein cholesterol (HDL-C) which will be measured by enzymatic colorimetric method) using commercial kits
DIAGNOSTIC_TEST	Serum vaspin	vaspin concentrations will be assayed using commercially available ELISA kits
DIAGNOSTIC_TEST	Serum resistin	resistin concentrations will be assayed using commercially available ELISA kits

Timeline

• Start date: 2016-04-25
• Primary completion: 2019-09-30
• Completion: 2019-10-01
• First posted: 2020-07-02
• Last updated: 2020-07-07