Trials / Unknown
UnknownNCT04439565
Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (estimated)
- Sponsor
- Chinese Medical Association · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | movement | aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention. |
Timeline
- Start date
- 2020-06-17
- Primary completion
- 2023-06-17
- Completion
- 2023-07-17
- First posted
- 2020-06-19
- Last updated
- 2020-06-19
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04439565. Inclusion in this directory is not an endorsement.