NCT04430426

Heterozygous Individuals for AGXT and Kidney Stones

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. Subjects will then be administered an intravenous (IV) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.

Conditions

• Kidney Stone

Interventions

Type	Name	Description
OTHER	Controlled Diet	Participants will consume a controlled low oxalate diet for five days.
OTHER	Glycolate Administration	Participants will come to the UAB Clinical Research Unit (CRU) and be administered a glycolate load via intravenous (IV) catheter.

Timeline

• Start date: 2026-07-01
• Primary completion: 2031-08-01
• Completion: 2032-08-01
• First posted: 2020-06-12
• Last updated: 2025-07-04