NCT04427904

Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery

Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery: A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 210 (estimated)
• Sponsor: St. Joseph's Healthcare Hamilton · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the efficacy of Bupivicaine and Lidocaine for postoperative pain control in thyroid surgery.

Detailed description

Patients planned for total thyroidectomy will be recruited for participation. After being informed about the study and potential risks, all patients giving written informed consent will be screened for eligibility for study entry. Patients that meet inclusion and exclusion criteria will be randomized via block randomization in a double blind fashion and a 1:1 ratio to surgical incision infiltration with Bupivacaine (0.5% with 1:200 000 epinephrine) or Lidocaine (2% with 1:100 000 epinephrine).

Conditions

• Postoperative Pain
• Thyroid Diseases
• Anesthesia, Local

Interventions

Type	Name	Description
DRUG	Bupivacaine 0.5% with 1:200 000 epinephrine	Bupivacaine 0.5% with 1:200 000 epinephrine. Total volume 10mL for local infiltration before neck incision.
DRUG	Lidocaine 2% with 1:100 000 epinephrine	Lidocaine 2% with 1:100 000 epinephrine. Total volume 10mL for local infiltration before neck incision.

Timeline

• Start date: 2022-06-01
• Primary completion: 2024-12-31
• Completion: 2025-12-31
• First posted: 2020-06-11
• Last updated: 2023-11-28

Locations

1 site across 1 country: Canada