NCT04414800

Intranasal Ketamine Versus Intranasal Fentanyl

Intranasal Ketamine Versus Intranasal Fentanyl on Pain Management in Isolated Traumatic Patients

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 125 (actual)
• Sponsor: Isfahan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 15 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Abstract Background: Given the inadequate control of pain in patients with injury that refer to the emergency departments, the rapid onset of action of intranasal administration in pain management, and the avoidance of administering opioid medications, the present study aimed at evaluating the effect of intranasal ketamine versus intranasal fentanyl on pain management in isolated traumatic patients Materials and Methods: The current study was performed on 125 patients that were divided into the following three groups: control group (n = 41), 1 mg/kg intranasal ketamine group (n = 40), and 1μg/kg intranasal fentanyl group (n = 44). Then pain scores, HR, RR, BP, and SaO2 were recorded at baseline, 5, 10, 15, 30, and 40 minutes after the intervention.

Conditions

• Multiple Trauma
• Pain, Acute

Interventions

Type	Name	Description
DRUG	Placebo	Distilled water
DRUG	Ketamine	1 mg/kg intranasal ketamine
DRUG	Fentanyl	1μg/kg intranasal fentanyl

Timeline

• Start date: 2017-04-01
• Primary completion: 2018-03-20
• Completion: 2018-04-15
• First posted: 2020-06-04
• Last updated: 2020-06-04

Locations

1 site across 1 country: Iran