NCT04413149

Anti-neutrophil Cytoplasmic Antibody in Interstitial Lung Disease.

Observational Study of Clinical Features and Outcome of Interstitial Lung Disease With Anti-neutrophil Cytoplasmic Antibody in Chinese Patients.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the clinical features and long-term outcome of anti-neutrophil cytoplasmic antibody (ANCA)-positive interstitial lung disease (ILD) and assess the difference between microscopic polyangiitis (MPA) associated ILD and isolated ANCA-positive idiopathic interstitial pneumonia.

Detailed description

ILD patients with serum ANCA-positivity were enrolled in this study. 1. Baseline data collection: 1. Demographics information (age, gender) 2. Clinical course 3. Clinical symptoms and signs (cough, dyspnea, fever, fatigue, crackling, clubbing fingers, mechanics hand) 4. Laboratory findings (blood and urine routine, liver and renal function tests, erythrocyte sedimentation rate, C reactive protein) 5. Serologic tests (ANA , Rheumatoid factor , Anti-cyclic citrullinated peptide (CCP), Anti-dsDNA, Anti-Ro (SS-A), Anti-La (SS-B), Anti-Smith, Anti-Scl-70, Anti-Jo-1) 6. Systemic manifestation if diagnosed as systemic vasculitis 7. Pulmonary function tests (ventilation and diffusion capacity test) 8. Chest high-resolution computed tomography (HRCT) 2. Treatment: treatment will be given according to the experience of each pulmonologist. 3. Follow-up: 1. Patients were followed up at least once a year and basic laboratory tests, serologic autoantibodies, pulmonary function test and chest HRCT were evaluated routinely 2. Follow-up end point was April 2019. 4. Outcome

Conditions

• Interstitial Lung Disease
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Timeline

• Start date: 2014-04-01
• Primary completion: 2019-04-01
• Completion: 2020-04-01
• First posted: 2020-06-02
• Last updated: 2024-05-17
• Results posted: 2024-05-17

Locations

1 site across 1 country: China